HCID 86659598, compound → HCID 86659599, compound

HRID 451325Notes

Reaction equation

HRID 451325 reaction equation
C([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([O:20][CH2:21][CH:22]1[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]1)=[O:19])C1C=CC=CC=1>CO.[Pd]>[OH:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([O:20][CH2:21][CH:22]1[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]1)=[O:19]

Participants

4

Reactant 1

HCID 86659598HCID 86659598, compound

Product 1

HCID 86659599HCID 86659599, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a mixture of the product of Step 1 (100 mg, 0.211 mmol) in methanol was added 10% palladium on carbon (6.74 mg). The reaction mixture was stirred under an atmosphere of hydrogen (balloon) overnight then filtered. The filtrate was concentrated under vacuum to afford the title compound which was used without purification in the next step.

Workup

  1. filtrationthen filtered
  2. concentrationThe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-ce5c215d9e1b4ab1a38b5a94ffb3e108
Source dataset
uspto-grants-2013_07
Patent number
US08487093B2

Reaction notes

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