Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | Tizanidine | HCID 5487 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 86658842 | HCID 86658842 | 91.4% |
Reaction Steps
To 7 ml of isopropyl alcohol, 3.0 g of the tizanidine base (99.15% HPLC) and 2.5 g of propionic acid are added. After brief heating to boil a yellowish solution results, from which a precipitated product starts to separate. After cooling to 0 to 5° C. and aspiration 3.53 g of tizanidine propionate are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08487113B2 |
|---|
| Source dataset | uspto-grants-2013_07 |
|---|
| ORD ID | ord-3d5707a5f4c7474fb6a89e3b83b7a395 |
|---|
| Source note | uspto-grants-2013_07 |
|---|
