Propionic Acid → HCID 86658842, compound

HRID 451345Notes

Reaction equation

HRID 451345 reaction equation
[CH:1]1[C:6]2=[N:7][S:8][N:9]=[C:5]2[C:4]([NH:10][C:11]2[NH:15][CH2:14][CH2:13][N:12]=2)=[C:3]([Cl:16])[CH:2]=1.[C:17]([OH:21])(=[O:20])[CH2:18][CH3:19]>C(O)(C)C>[CH:1]1[C:6]2=[N:7][S:8][N:9]=[C:5]2[C:4]([NH:10][C:11]2[NH:15][CH2:14][CH2:13][N:12]=2)=[C:3]([Cl:16])[CH:2]=1.[C:17]([O-:21])(=[O:20])[CH2:18][CH3:19]

Participants

4

Reactant 2

HCID 1032Propionic AcidHCID 5487Tizanidine

Product 1

HCID 86658842HCID 86658842, compoundYield 91.4%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
2.5 °C

Procedure

To 7 ml of isopropyl alcohol, 3.0 g of the tizanidine base (99.15% HPLC) and 2.5 g of propionic acid are added. After brief heating to boil a yellowish solution results, from which a precipitated product starts to separate. After cooling to 0 to 5° C. and aspiration 3.53 g of tizanidine propionate are obtained.

Workup

  1. temperatureAfter brief heating
  2. customresults, from which a precipitated product starts
  3. customto separate

Sources & evidence

ORD record
ord-3d5707a5f4c7474fb6a89e3b83b7a395
Source dataset
uspto-grants-2013_07
Patent number
US08487113B2

Reaction notes

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