Tizanidine → HCID 86658843, compound

HRID 451346Notes

Reaction equation

HRID 451346 reaction equation
[CH:1]1[C:6]2=[N:7][S:8][N:9]=[C:5]2[C:4]([NH:10][C:11]2[NH:15][CH2:14][CH2:13][N:12]=2)=[C:3]([Cl:16])[CH:2]=1.[C:17]([OH:24])(=[O:23])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]>C(O)C>[CH:1]1[C:6]2=[N:7][S:8][N:9]=[C:5]2[C:4]([NH:10][C:11]2[NH:15][CH2:14][CH2:13][N:12]=2)=[C:3]([Cl:16])[CH:2]=1.[C:17]([O-:24])(=[O:23])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22]

Participants

4

Reactant 2

HCID 5487TizanidineHCID 8892Hexanoic Acid

Product 1

HCID 86658843HCID 86658843, compoundYield 74.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
2.5 °C

Procedure

To 5 ml of ethanol, 3.0 g of the tizanidine base (99.15% HPLC) and 2.5 g of hexanoic acid are added. After brief heating to boil a yellowish solution results, from which a precipitated product starts to separate. After cooling to 0 to 5° C. and aspiration 3.25 g of tizanidine hexanoate are obtained.

Workup

  1. temperatureAfter brief heating
  2. customresults, from which a precipitated product starts
  3. customto separate

Sources & evidence

ORD record
ord-b6434f6d602b4003a6cf9b2cf7004701
Source dataset
uspto-grants-2013_07
Patent number
US08487113B2

Reaction notes

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