1-[3-(trifluoromethyl)benzyl]-1H-1,2,4-triazol-3-amine → [1-(3-Methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-yl]-amine

HRID 451384Notes

Reaction equation

HRID 451384 reaction equation
[CH3:1][C:2]1[N:6]=[C:5]([N:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[S:4][N:3]=1.[F:14][C:15]([F:30])([F:29])[C:16]1[CH:17]=[C:18]([CH:26]=[CH:27][CH:28]=1)[CH2:19][N:20]1[CH:24]=[N:23][C:22]([NH2:25])=[N:21]1>>[CH3:1][C:2]1[N:6]=[C:5]([N:7]2[CH2:12][CH2:11][CH:10]([NH:25][C:22]3[N:23]=[CH:24][N:20]([CH2:19][C:18]4[CH:26]=[CH:27][CH:28]=[C:16]([C:15]([F:30])([F:14])[F:29])[CH:17]=4)[N:21]=3)[CH2:9][CH2:8]2)[S:4][N:3]=1

Participants

3

Reactant 2

HCID 70193291-[3-(trifluoromethyl)benzyl]-1H-1,2,4-triazol-3-amineHCID 592585101-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one

Product 1

HCID 53354730[1-(3-Methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-[1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-yl]-amine

Procedure

Prepared in analogy to example 1 step h) starting from 1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-one (example 1c) and 1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a white solid.

Workup

  1. customPrepared in analogy to example 1 step h)

Sources & evidence

ORD record
ord-6c4340a40d3a4033931925a3c333f1fa
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

Loading…