1-((2,4-Dichlorophenyl)methyl)-1H-pyrazol-3-amine → [1-(2,4-Dichloro-benzyl)-1H-pyrazol-3-yl]-[1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-amine

HRID 451389Notes

Reaction equation

HRID 451389 reaction equation
[CH3:1][C:2]1[N:6]=[C:5]([N:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[S:4][N:3]=1.[Cl:14][C:15]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:16]=1[CH2:17][N:18]1[CH:22]=[CH:21][C:20]([NH2:23])=[N:19]1>>[Cl:14][C:15]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:16]=1[CH2:17][N:18]1[CH:22]=[CH:21][C:20]([NH:23][CH:10]2[CH2:11][CH2:12][N:7]([C:5]3[S:4][N:3]=[C:2]([CH3:1])[N:6]=3)[CH2:8][CH2:9]2)=[N:19]1

Participants

3

Reactant 2

HCID 53027431-((2,4-Dichlorophenyl)methyl)-1H-pyrazol-3-amineHCID 592585101-(3-Methyl-1,2,4-thiadiazol-5-yl)piperidin-4-one

Product 1

HCID 53354736[1-(2,4-Dichloro-benzyl)-1H-pyrazol-3-yl]-[1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-yl]-amine

Procedure

Prepared in analogy to example 1 step h) starting from 1-(3-methyl-[1,2,4]thiadiazol-5-yl)-piperidin-4-one (example 1c) and 1-(2,4-dichloro-benzyl)-1H-pyrazol-3-ylamine. The title compound was obtained as a colorless oil (yield=56%).

Workup

  1. customPrepared in analogy to example 1 step h)

Sources & evidence

ORD record
ord-0e95c66d07824572a5969d70c2e3b0c6
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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