Hydrochloric Acid → 1-(2-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride

HRID 451409Notes

Reaction equation

HRID 451409 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH3:20])[N:15]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:22]>C(Cl)Cl.C(OCC)C>[ClH:22].[ClH:22].[CH3:20][C:16]1[N:15]=[C:14]([N:11]2[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]2)[CH:19]=[CH:18][N:17]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67343389[1-(2-Methyl-pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Product 1

HCID 673429791-(2-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of [1-(2-methyl-pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester (818.7 mg, 2.8 mmol) in CH2Cl2 (14 mL) was added at room temperature under stirring a 2 M HCl solution in diethyl ether (7 mL) and was stirred at room temperature over the weekend. The solvent was removed under reduced pressure and the residue was treated twice with diethyl ether. The title compound was obtained after removal of the solvent under reduced pressure as a light brown solid (869 mg, 100%)

Workup

  1. customThe solvent was removed under reduced pressure
  2. additionthe residue was treated twice with diethyl ether

Sources & evidence

ORD record
ord-e9caa491d0c7436ba27c19aedcd6fa28
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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