Hydrochloric Acid → 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride

Participants

Reaction Steps

To a solution of [1-(6-methyl-pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester (686 mg, 2.3 mmol) in CH2Cl2 (12 mL) was added at room temperature under stirring a 2 M HCl solution in diethyl ether (6 mL) and was stirred at room temperature over night. The precipitate was filtered off, washed with CH2Cl2 and diethyl ether and dried to yield the title compound as a light yellow solid (610 mg, 98%)

Provenance & Evidence