Hydrochloric Acid → 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride

HRID 451413Notes

Reaction equation

HRID 451413 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([CH3:20])[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:22]>C(Cl)Cl.C(OCC)C>[ClH:22].[ClH:22].[CH3:20][C:18]1[N:17]=[CH:16][N:15]=[C:14]([N:11]2[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]2)[CH:19]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67343276tert-butyl N-[1-(6-methylpyrimidin-4-yl)piperidin-4-yl]carbamate

Product 1

HCID 673421331-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochlorideYield 98%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of [1-(6-methyl-pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester (686 mg, 2.3 mmol) in CH2Cl2 (12 mL) was added at room temperature under stirring a 2 M HCl solution in diethyl ether (6 mL) and was stirred at room temperature over night. The precipitate was filtered off, washed with CH2Cl2 and diethyl ether and dried to yield the title compound as a light yellow solid (610 mg, 98%)

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with CH2Cl2 and diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-ca0cd090324e4745a7c2a7619e98f9cf
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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