反应详情

To a solution of 6-methyl-pyridin-2-ylamine (50 g, 0.462 mol) in acetic anhydride (200 mL) was heated to 90° C. for 90 minutes. The reaction mixture was cooled to room temperature and evaporated. An aqueous saturated solution of NaHCO3 was added to the residue until pH 8. The aqueous phase was extracted with ethyl acetate, the combined organic phases were dried over sodium sulfate, and the solvent was evaporated. The title compound was obtained as a white solid (68 g, 98%).

1. customevaporated
2. additionAn aqueous saturated solution of NaHCO3 was added to the residue until pH 8
3. extractionThe aqueous phase was extracted with ethyl acetate
4. dry with materialthe combined organic phases were dried over sodium sulfate
5. customthe solvent was evaporated