Sodium Hydroxide → 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine

HRID 451469Notes

Reaction equation

HRID 451469 reaction equation
Cl.Cl.[CH3:3][C:4]1[N:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12][CH2:11]2)[CH:5]=1.[OH-].[Na+]>C(Cl)Cl>[CH3:3][C:4]1[N:9]=[CH:8][N:7]=[C:6]([N:10]2[CH2:15][CH2:14][CH:13]([NH2:16])[CH2:12][CH2:11]2)[CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 673421331-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride

Product 1

HCID 166433141-(6-Methylpyrimidin-4-yl)piperidin-4-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride (see example 30b, 2 g, 7.54 mmol) was neutralized with 2 N NaOH solution and CH2Cl2, the aqueous layers were extracted three times with CH2Cl2, the combines organic layers were dried over Na2SO4, filtered and the solvent was evaporated. The title compound was obtained as a brown oil (1.31 g, 90%).

Workup

  1. extractionthe aqueous layers were extracted three times with CH2Cl2
  2. dry with materialthe combines organic layers were dried over Na2SO4
  3. filtrationfiltered
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-d1a97e2157054c4bac830b1e9fca58d2
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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