反应详情

1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride (see example 30b, 2 g, 7.54 mmol) was neutralized with 2 N NaOH solution and CH2Cl2, the aqueous layers were extracted three times with CH2Cl2, the combines organic layers were dried over Na2SO4, filtered and the solvent was evaporated. The title compound was obtained as a brown oil (1.31 g, 90%).

1. extractionthe aqueous layers were extracted three times with CH2Cl2
2. dry with materialthe combines organic layers were dried over Na2SO4
3. filtrationfiltered
4. customthe solvent was evaporated