HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride | HCID 67342133 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine | HCID 16643314 | — |
Reaction Steps
1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride (see example 30b, 2 g, 7.54 mmol) was neutralized with 2 N NaOH solution and CH2Cl2, the aqueous layers were extracted three times with CH2Cl2, the combines organic layers were dried over Na2SO4, filtered and the solvent was evaporated. The title compound was obtained as a brown oil (1.31 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486967B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-d1a97e2157054c4bac830b1e9fca58d2 |
| Source note | uspto-grants-2013_07 |