HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Aminomethyl)benzeneboronic acid, N-BOC protected → [3-(2-Amino-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-benzyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Aminomethyl)benzeneboronic acid, N-BOC protected | HCID 3684686 | — |
| Reactant | 8-Bromo-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine | HCID 21464338 | — |
| Product | [3-(2-Amino-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-benzyl]-carbamic acid tert-butyl ester | HCID 67335256 | — |
Reaction Steps
Prepared in analogy to example 160b, starting from 8-bromo-6-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine and 3-((tert-butoxycarbonylamino)methyl)phenylboronic acid. The title compound was obtained as an off-white solid (yield: 99%) after precipitation from diethyl ether. MS ISP (m/e): 354.4 (80) [(M+H)+], 298.4 (100), 237.2 (99).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08486967B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-1f85a5d8ff074d9d9653eaea70fe8924 |
| Source note | uspto-grants-2013_07 |