Hydrochloric Acid → HCID 67342484, compound

HRID 451486Notes

Reaction equation

HRID 451486 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:25]2[CH:26]=[C:27]([CH:37]=[CH:38][CH:39]=2)[CH2:28][NH:29]C(=O)OC(C)(C)C)[C:5]2[N:6]([N:8]=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][N:15]([C:18]4[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20][N:19]=4)[CH2:14][CH2:13]3)[N:10]=2)[CH:7]=1.[ClH:40]>C(Cl)Cl.CCOCC>[ClH:40].[ClH:40].[NH2:29][CH2:28][C:27]1[CH:26]=[C:25]([C:4]2[C:5]3[N:6]([N:8]=[C:9]([NH:11][CH:12]4[CH2:13][CH2:14][N:15]([C:18]5[CH:23]=[C:22]([CH3:24])[N:21]=[CH:20][N:19]=5)[CH2:16][CH2:17]4)[N:10]=3)[CH:7]=[C:2]([CH3:1])[CH:3]=2)[CH:39]=[CH:38][CH:37]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67343427HCID 67343427, compound

Product 1

HCID 67342484HCID 67342484, compoundYield 89%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 3-(6-methyl-2-(1-(6-methylpyrimidin-4-yl)piperidin-4-ylamino)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzylcarbamate (46 mg, 87.0 μmol) in methylene chloride (1 mL) was added 2 M solution of HCl in Ether (500 μL). The suspension was stirred at room temperature over night. The solvent was decanted and the residue was digerated with diethyl ether three times. The title compound was dried under reduced pressure and was obtained as a yellow solid (39 mg, 89%). MS ISP (m/e): 429.3 (100) [(M+H)+], 412.4 (57).

Workup

  1. customThe solvent was decanted
  2. dry with materialThe title compound was dried under reduced pressure

Sources & evidence

ORD record
ord-0738f7ef6465464898f6e2c1113b67ed
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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