1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride → 4-(3-Chloro-4-fluorophenyl)-6-methyl-N-(1-(6-methylpyrimidin-4-yl)piperidin-4-yl)benzo[d]thiazol-2-amine

HRID 451515Notes

Reaction equation

HRID 451515 reaction equation
Br[C:2]1[S:3][C:4]2[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[C:14]([Cl:19])[CH:13]=3)[C:5]=2[N:6]=1.Cl.Cl.[CH3:22][C:23]1[N:28]=[CH:27][N:26]=[C:25]([N:29]2[CH2:34][CH2:33][CH:32]([NH2:35])[CH2:31][CH2:30]2)[CH:24]=1>>[Cl:19][C:14]1[CH:13]=[C:12]([C:7]2[C:5]3[N:6]=[C:2]([NH:35][CH:32]4[CH2:33][CH2:34][N:29]([C:25]5[CH:24]=[C:23]([CH3:22])[N:28]=[CH:27][N:26]=5)[CH2:30][CH2:31]4)[S:3][C:4]=3[CH:10]=[C:9]([CH3:11])[CH:8]=2)[CH:17]=[CH:16][C:15]=1[F:18]

Participants

3

Reactant 2

HCID 673421331-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochlorideHCID 673424052-Bromo-4-(3-chloro-4-fluorophenyl)-6-methylbenzo[d]thiazole

Product 1

HCID 866567144-(3-Chloro-4-fluorophenyl)-6-methyl-N-(1-(6-methylpyrimidin-4-yl)piperidin-4-yl)benzo[d]thiazol-2-amine

Procedure

Prepared in analogy to example 207d, starting from 2-bromo-4-(3-chloro-4-fluorophenyl)-6-methylbenzo[d]thiazole and 1-(6-methyl-pyrimidin-4-yl)-piperidin-4-ylamine dihydrochloride. The title compound was obtained as a white solid.

Workup

  1. customPrepared in analogy to example 207d

Sources & evidence

ORD record
ord-50a7797ad8f9437eb9cd9ea1a6a5bc36
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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