3-(4-Fluoropiperidin-1-yl)-2-nitropyridine → 3-(4-Fluoropiperidin-1-yl)pyridin-2-amine

HRID 451517Notes

Reaction equation

HRID 451517 reaction equation
[F:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:9]([N+:14]([O-])=O)=[N:10][CH:11]=[CH:12][CH:13]=2)[CH2:4][CH2:3]1>CO>[F:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]2[C:9]([NH2:14])=[N:10][CH:11]=[CH:12][CH:13]=2)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 673355063-(4-Fluoropiperidin-1-yl)-2-nitropyridine

Product 1

HCID 673359413-(4-Fluoropiperidin-1-yl)pyridin-2-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3-(4-fluoropiperidin-1-yl)-2-nitropyridine (2.0 g, 8.9 mmol) in methanol (25 mL) was added a generous spoon of rainey-nickel and the mixture stirred under an atmosphere of hydrogen for 5 hours. The reaction was then filtered over Hyflo and the solvent was evaporated in vacuo to afford the product used without need for further purification. The title compound was obtained as a dark brown solid (1.7 g, 100%).

Workup

  1. filtrationThe reaction was then filtered over Hyflo
  2. customthe solvent was evaporated in vacuo
  3. customto afford the product
  4. customused without need for further purification

Sources & evidence

ORD record
ord-362c2c603be24fee991df04488b4636c
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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