3-(4-Fluoropiperidin-1-yl)-2-nitropyridine → 3-(4-Fluoropiperidin-1-yl)pyridin-2-amine

Participants

Reaction Steps

To a solution of 3-(4-fluoropiperidin-1-yl)-2-nitropyridine (2.0 g, 8.9 mmol) in methanol (25 mL) was added a generous spoon of rainey-nickel and the mixture stirred under an atmosphere of hydrogen for 5 hours. The reaction was then filtered over Hyflo and the solvent was evaporated in vacuo to afford the product used without need for further purification. The title compound was obtained as a dark brown solid (1.7 g, 100%).

Provenance & Evidence