Hydrochloric Acid → HCID 58398047, compound

HRID 451540Notes

Reaction equation

HRID 451540 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH:18][C@@H:19]4[CH2:24][CH2:23][N:22]([C:25](OC(C)(C)C)=O)[CH2:21][C@@H:20]4[O:32][CH3:33])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[F:8].Cl>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:10]3[N:11]([N:15]=[C:16]([NH:18][C@@H:19]4[CH2:24][CH2:23][N:22]([C:25]5[CH:20]=[C:19]([CH3:24])[N:18]=[CH:16][N:15]=5)[CH2:21][C@@H:20]4[O:32][CH3:33])[N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67344414HCID 67344414, compound

Product 1

HCID 58398047HCID 58398047, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution (3S,4R)-tert-butyl 4-(8-(3,4-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-3-methoxypiperidine-1-carboxylate (37 mg, 80.5 mol) in dichloromethane (1 mL) was added HCl (2 M in diethylether, 201 L, 403 mol) and the reaction mixture was stirred at room temperature for 18 hours. The mixture was then filtered and the white precipitate was washed with dichloromethane and diethylether and dried to afford the title compound (32 mg, 92%) as an off white solid.

Workup

  1. filtrationThe mixture was then filtered
  2. washthe white precipitate was washed with dichloromethane and diethylether
  3. customdried

Sources & evidence

ORD record
ord-838fddfddabb42258692d0d75fca75cd
Source dataset
uspto-grants-2013_07
Patent number
US08486967B2

Reaction notes

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