反应详情

温度

65 °C

5-tert-Butyl-2,3-dihydro-1H-inden-1-ylamine (25.51 g, 93% potency), N-acetyl-(L)-leucine (23.34 g), and methanol (315 mL) were combined and heated at 65° C. for 1 hour. The solution was allowed to cool to ambient temperature. The solids were filtered and washed with toluene. The solid was then resuspended in methanol (125 mL) and brought to reflux. The solution was allowed to cool to ambient temperature and the solids were filtered. The solid was dried at 40° C. under reduced pressure to provide the title compound (98.7% ee).

1. temperatureto cool to ambient temperature
2. filtrationThe solids were filtered
3. washwashed with toluene
4. temperatureto reflux
5. temperatureto cool to ambient temperature
6. filtrationthe solids were filtered
7. customThe solid was dried at 40° C. under reduced pressure