HRID451673

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCC[C@@H]([C@@H](OCCO[Si](C)(C)C(C)(C)C)c2cccc(Cl)c2)C1

HCID59201708

未命名化合物

PRODUCTS

生成物

结构：OCCO[C@@H](c1cccc(Cl)c1)[C@@H]1CCCNC1

HCID59201741

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of crude (R)-tert-butyl 3-((R)-(2-(tert-butyldimethylsilyloxy)ethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate in CH3CN (100 mL) and 2 N aq HCl (100 mL) was vigorously stirred at rt for 2 d. The solvents were removed in vacuo to give the HCl salt of 2-((R)-(3-chlorophenyl)((R)-piperidin-3-yl)methoxy)ethanol, which was used in the next step without further purification. LC-MS (3 min) tR=1.05 min m/z 272, 270 (M+H)+.

WORKUP

后处理

customThe solvents were removed in vacuo