huagongshe.com
HRID451771

反应详情

EQUATION

反应方程式

HRID 451771 的结构方程式

REACTANTS

反应物

2
结构：C[Si](C)(C)CCOC(=O)ON1C(=O)CCC1=O
HCID5018386

1-({[2-(Trimethylsilyl)ethoxy]carbonyl}oxy)pyrrolidine-2,5-dione

C10H17NO5Si

结构：CCC(NC)[C@H](CC1CCCCC1)NC(=O)OC(C)(C)C
HCID59201714

未命名化合物

PRODUCTS

生成物

1
结构：CCC([C@H](CC1CCCCC1)NC(=O)OC(C)(C)C)N(C)C(=O)OCC[Si](C)(C)C
HCID68713330

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To the solution of (S)-tert-butyl 1-cyclohexyl-3-(methylamino)pentan-2-ylcarbamate in THF (20 mL) was added TeocOSu (398 mg, 1.53 mmol), followed by TEA (0.5 mL). The reaction mixture was stirred for 30 min at rt, and concentrated. The residue was partially purified through chromatography on silica gel to give (2S)-tert-butyl 1-cyclohexyl-3-(N-methyl-N-(2-(trimethylsilyl)ethoxycarbonyl)amino)pentan-2-ylcarbamate. MS ESI +ve m/z 465 (M+Na).

WORKUP

后处理

  1. concentrationconcentrated
  2. customThe residue was partially purified through chromatography on silica gel