HCID 59201315, compound → HCID 59201463, compound

HRID 451893Notes

Reaction equation

HRID 451893 reaction equation
[CH:1]1([C@H:7]([OH:43])[C@H:8]([NH:19][C:20]([N:22]2[CH2:27][CH2:26][CH2:25][C@@H:24]([C@H:28]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[O:29][CH2:30][CH2:31][NH:32][C:33](=[O:36])[O:34][CH3:35])[CH2:23]2)=[O:21])[CH2:9][N:10](C)[C:11](OC(C)(C)C)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(Cl)Cl>[CH:1]1([C@H:7]([OH:43])[C@H:8]([NH:19][C:20]([N:22]2[CH2:27][CH2:26][CH2:25][C@@H:24]([C@H:28]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[O:29][CH2:30][CH2:31][NH:32][C:33](=[O:36])[O:34][CH3:35])[CH2:23]2)=[O:21])[CH2:9][NH:10][CH3:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 1

HCID 59201315HCID 59201315, compound

Product 1

HCID 59201463HCID 59201463, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of methyl 2-((R)—((R)-1-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(N-methyl-N-(tert-butoxycarbonyl)amino)propan-2-ylcarbamoyl)piperidin-3-yl)(phenyl)methoxy)ethylcarbamate in 20% (V/V) CH2Cl2 (1 mL) was stirred for 1 h. The solution was evaporated under reduced pressure and the residue purified via prep HPLC to afford methyl 2-((R)—((R)-1-((1S,2R)-1-cyclohexyl-1-hydroxy-3-(methylamino)propan-2-ylcarbamoyl)piperidin-3-yl)(phenyl)methoxy)ethylcarbamate (1.01 mg).

Workup

  1. customThe solution was evaporated under reduced pressure
  2. customthe residue purified via prep HPLC

Sources & evidence

ORD record
ord-13e3029a6c504698a0f21dcefcdec60a
Source dataset
uspto-grants-2013_07
Patent number
US08487108B2

Reaction notes

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