反应详情

To a solution of (S)-tert-butyl 2-amino-3-cyclohexylpropyl(methyl)carbamate (1.08 g, 4 mmol) in CH3CN (15 mL) and Et3N (3 mL) was added dimethyl cyanocarbonimidodithioate (642 mg, 4.4 mmol). The mixture was heated to reflux for 4 h. The reaction mixture was concentrated to give the residue, which was purified by column to give (S)-tert-butyl 2-((cyanoimino)(methylthio)methylamino)-3-cyclohexylpropyl(methyl)carbamate (450 mg, 31%).

1. temperatureThe mixture was heated
2. temperatureto reflux for 4 h
3. concentrationThe reaction mixture was concentrated
4. customto give the residue, which
5. customwas purified by column