反应详情

Crude 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1-phenyl-ethylamine (26, 2.5 g) was dissolved in acetone (40 mL) and treated with 6M aqueous hydrochloric acid (21.1 mL). After 5 hours stirring the mixture was evaporated at less than 20° C. to give a residue which was treated with dichloromethane, washed with saturated sodium bicarbonate solution, dried and filtered to give a solution of crude product which was used immediately. Rt=0.7 min (Method 5). Detected mass: 218.3 (M+H+).

1. customwas evaporated at less than 20° C.
2. customto give a residue which
3. washwashed with saturated sodium bicarbonate solution
4. customdried
5. filtrationfiltered
6. customto give a solution of crude product which