5-Aminobenzimidazole → HCID 178489837, compound

HRID 452058Notes

Reaction equation

HRID 452058 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.N1([C:16]([N:18]2[CH:22]=[CH:21]N=C2)=[O:17])C=CN=C1.Cl.NCC([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=1)=O>>[NH:6]1[C:5]2[CH:9]=[CH:10][C:2]([N:1]3[CH:21]([C:28]4[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=4)[CH2:22][NH:18][C:16]3=[O:17])=[CH:3][C:4]=2[N:8]=[CH:7]1

Participants

4

Reactant 3

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 222816642-(3-Methoxy-phenyl)-2-oxo-ethyl-ammonium, chloride

Product 1

HCID 178489837HCID 178489837, compound

Procedure

The compound was synthesized as hydrochloride salt starting from 5-aminobenzimidazole (0.532 g, 4 mmol), di(1H-imidazol-1-yl)methanone (0.713 g, 4.4 mmol), TEA (1.67 mL, 12 mmol), aminomethyl-(3-methoxyphenyl)ketone hydrochloride (0.807 g, 4 mmol), TEA (1.12 mL, 8 mmol), PdC (10%, 0.02 g) as described in method 1.

Sources & evidence

ORD record
ord-bd1274cae8c64f93b0fc5bfe4b62ae78
Source dataset
uspto-grants-2013_07
Patent number
US08486940B2

Reaction notes

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