5-Aminobenzimidazole → HCID 178517663, compound

HRID 452072Notes

Reaction equation

HRID 452072 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.N1([C:16]([N:18]2[CH:22]=[CH:21]N=C2)=[O:17])C=CN=C1.Cl.NCC([C:28]1[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=1)=O>>[NH:6]1[C:5]2[CH:9]=[CH:10][C:2]([N:1]3[CH:21]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=4)[CH2:22][NH:18][C:16]3=[O:17])=[CH:3][C:4]=2[N:8]=[CH:7]1

Participants

4

Reactant 3

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 132906662-Amino-1-(4-fluorophenyl)ethan-1-one hydrochloride

Product 1

HCID 178517663HCID 178517663, compound

Procedure

The compound was synthesized as hydrochloride salt starting from 5-aminobenzimidazole (0.665 g, 5 mmol), di(1H-imidazol-1-yl)methanone (0.891 g, 5.5 mmol), TEA (2.09 mL, 15 mmol), aminomethyl-(4-fluorophenyl)ketone hydrochloride (0.948 g, 5 mmol), TEA (1.39 mL, 10 mmol), PdC (10%, 0.02 g) as described in method 1.

Sources & evidence

ORD record
ord-5a220afddf0248549360c5010fd0535a
Source dataset
uspto-grants-2013_07
Patent number
US08486940B2

Reaction notes

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