1-Iodopropane → 3-Fluoro-4-propoxybenzaldehyde

HRID 452109Notes

Reaction equation

HRID 452109 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].I[CH2:12][CH2:13][CH3:14]>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH2:12][CH2:13][CH3:14])[CH:5]=[O:6]

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 5872503-Fluoro-4-hydroxybenzaldehyde

Product 1

HCID 574319263-Fluoro-4-propoxybenzaldehyde

Procedure

3-Fluoro-4-propoxybenzaldehyde was synthesized starting from 3-fluoro-4-hydroxybenzaldehyde (0.83 g, 5.95 mmol) and 1-iodopropane (1.16 ml, 11.9 mmol) according to reaction conditions described by Liou et al., J. Med. Chem. 2004, 47 (11), 2903.

Workup

  1. customaccording to reaction conditions

Sources & evidence

ORD record
ord-fe7d0d76e5344652850f1801518b32e6
Source dataset
uspto-grants-2013_07
Patent number
US08486940B2

Reaction notes

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