1-Fluoro-2-methoxy-4-nitrobenzene → HCID 59536597, compound

HRID 452213Notes

Reaction equation

HRID 452213 reaction equation
[Si:1]([O:18][CH2:19][C:20]1[C:21](=[O:26])[NH:22][CH:23]=[CH:24][CH:25]=1)([C:14]([CH3:17])([CH3:16])[CH3:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[C:28]1[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][C:29]=1[O:37][CH3:38]>>[Si:1]([O:18][CH2:19][C:20]1[C:21](=[O:26])[N:22]([C:28]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][C:29]=2[O:37][CH3:38])[CH:23]=[CH:24][CH:25]=1)([C:14]([CH3:17])([CH3:15])[CH3:16])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 144519681-Fluoro-2-methoxy-4-nitrobenzeneHCID 594101563-({[tert-Butyl(diphenyl)silyl]oxy}methyl)pyridin-2(1H)-one

Product 1

HCID 59536597HCID 59536597, compound

Procedure

Analogously to Example 4A, 5.00 g (13.8 mmol) of the compound from Example 3A are reacted with 2.59 g (15.1 mmol) of 1-fluoro-2-methoxy-4-nitrobenzene. The product is purified by chromatography on silica gel (mobile phase pentane/ethyl acetate=5:1), giving 2.70 g (38% of theory) of the title compound.

Workup

  1. customThe product is purified by chromatography on silica gel (mobile phase pentane/ethyl acetate=5:1)

Sources & evidence

ORD record
ord-ef255e550a4641abb9ea742051007ba2
Source dataset
uspto-grants-2013_07
Patent number
US08487111B2

Reaction notes

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