反应详情

The title compound was prepared from Intermediate 2 (200 mg, 0.763 mmol) in dichloromethane (10 ml) and [2-(cyclopentyloxy)-3-methoxyphenyl]acetic acid (283 mg, 1.153 mmol) in presence of EDCI.HCl (221 mg, 1.153 mmol), HOBt (178 mg, 1.153 mmol) and triethylamine (321 μl, 2.307 mmol) as described in Example 1 to give 236 mg of the product as a white solid; IR (KBr) 3311, 2963, 1653, 1529, 1476, 1266, 813 cm−1; 1H NMR (300 MHz, CDCl3) δ 1.58-1.64 (m, 6H), 1.70-1.80 (m, 6H), 1.97-2.04 (m, 1H), 2.13 (t, J=7.8 Hz, 2H), 2.26-2.33 (m, 2H), 3.58 (q, J=14.4 Hz, 2H), 3.81 (s, 3H), 4.99 (br s, 1H), 5.09-5.17 (m, 1H), 6.31 (d, J=8.1 Hz, 1H), 6.66 (t, J=8.4 Hz, 1H), 6.81-7.02 (m, 4H).