反应详情

The title compound was prepared from Intermediate 2 (218 mg, 1.053 mmol) and 1,2,3,4-tetrahydronaphthalen-2-ylacetic acid (200 mg, 1.053 mmol) in presence of EDCI.HCl (302 mg, 1.585 mmol), HOBt (241 mg, 1.585 mmol) and triethylamine (439 μl, 3.165 mmol) in dichloromethane (10 ml) as described in Example 1 to give 40 mg of the product as a white solid; IR (KBr) 3250, 2931, 2343, 1635, 1474, 1232, 738 cm−1; 1H NMR (300 MHz, CDCl3) δ 1.67-1.82 (m, 3H), 1.83-1.95 (m, 2H), 2.21-2.29 (m, 3H), 2.30-2.39 (m, 4H), 2.48-2.59 (m, 1H), 2.85-2.96 (m, 3H), 5.32 (q, J=7.8 Hz, 1H), 5.59 (d, J=7.8 Hz, 1H), 6.73 (d, J=8.4 Hz, 1H), 6.73 (d, J=8.4 Hz, 1H), 7.08-7.14 (m, 6H); ESI-MS (m/z) 396.95 (M+H)+.