Triethylamine → HCID 44132599, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	2-(1,2,3,4-Tetrahydronaphthalen-2-yl)acetic acid	HCID 10012739	—
Reactant	2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-amine	HCID 15338705	—
Solvent	Dichloromethane	HCID 6344	—
Product	HCID 44132599	HCID 44132599	—

Reaction Steps

The title compound was prepared from Intermediate 2 (218 mg, 1.053 mmol) and 1,2,3,4-tetrahydronaphthalen-2-ylacetic acid (200 mg, 1.053 mmol) in presence of EDCI.HCl (302 mg, 1.585 mmol), HOBt (241 mg, 1.585 mmol) and triethylamine (439 μl, 3.165 mmol) in dichloromethane (10 ml) as described in Example 1 to give 40 mg of the product as a white solid; IR (KBr) 3250, 2931, 2343, 1635, 1474, 1232, 738 cm−1; 1H NMR (300 MHz, CDCl3) δ 1.67-1.82 (m, 3H), 1.83-1.95 (m, 2H), 2.21-2.29 (m, 3H), 2.30-2.39 (m, 4H), 2.48-2.59 (m, 1H), 2.85-2.96 (m, 3H), 5.32 (q, J=7.8 Hz, 1H), 5.59 (d, J=7.8 Hz, 1H), 6.73 (d, J=8.4 Hz, 1H), 6.73 (d, J=8.4 Hz, 1H), 7.08-7.14 (m, 6H); ESI-MS (m/z) 396.95 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08487121B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-a9f41701ea1940f2aca1922256663164
Source note	uspto-grants-2013_07