反应详情

This compound was prepared from Intermediate 2 (200 mg, 0.894 mmol) and (2E)-3-quinolin-2-ylacrylic acid (213 mg, 1.073 mmol) in presence of EDCI.HCl (257 mg, 1.342 mmol), HOBt (205 mg, 1.342 mmol) and triethylamine (248 μl, 2.684 mmol) in dichloromethane (10 ml) as described in Example 1 to give 167 mg of the product as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.69-1.92 (m, 3H), 2.04-2.16 (m, 3H), 2.27-2.41 (m, 2H), 5.20 (q, J=10.2 Hz, 1H), 6.81 (d, J=9.0 Hz, 1H), 7.10-7.20 (m, 2H), 7.27 (d, J=15.6 Hz, 1H), 7.60 (t, J=7.8 Hz, 1H), 7.73-7.77 (m, 2H), 7.92-7.99 (m, 2H), 8.29 (s, 1H), 8.40 (d, J=8.1 Hz, 1H), 8.88 (d, J=8.4 Hz, 1H).