Triethylamine → (2E)-N-(6-Chloro-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)-3-quinolin-2-ylacrylamide

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	1-Hydroxybenzotriazole	HCID 75771	—
Reactant	3-(2-Quinolinyl)-2-propenoic acid	HCID 712919	—
Reactant	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
Reactant	2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-amine	HCID 15338705	—
Solvent	Dichloromethane	HCID 6344	—
Product	(2E)-N-(6-Chloro-3,4-dihydrospiro[chromene-2,1'-cyclobutan]-4-yl)-3-quinolin-2-ylacrylamide	HCID 68790685	46.1%

Reaction Steps

This compound was prepared from Intermediate 2 (200 mg, 0.894 mmol) and (2E)-3-quinolin-2-ylacrylic acid (213 mg, 1.073 mmol) in presence of EDCI.HCl (257 mg, 1.342 mmol), HOBt (205 mg, 1.342 mmol) and triethylamine (248 μl, 2.684 mmol) in dichloromethane (10 ml) as described in Example 1 to give 167 mg of the product as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.69-1.92 (m, 3H), 2.04-2.16 (m, 3H), 2.27-2.41 (m, 2H), 5.20 (q, J=10.2 Hz, 1H), 6.81 (d, J=9.0 Hz, 1H), 7.10-7.20 (m, 2H), 7.27 (d, J=15.6 Hz, 1H), 7.60 (t, J=7.8 Hz, 1H), 7.73-7.77 (m, 2H), 7.92-7.99 (m, 2H), 8.29 (s, 1H), 8.40 (d, J=8.1 Hz, 1H), 8.88 (d, J=8.4 Hz, 1H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08487121B2
Source dataset	uspto-grants-2013_07
ORD ID	ord-c4aae4a288534859969b5d1a812c525f
Source note	uspto-grants-2013_07