反应详情

The title compound was prepared from Intermediate 2 (250 mg, 0.965 mmol) and 4-(4-methoxy-1-naphthyl)-4-oxobutanoic acid (274 mg, 1.062 mmol) in presence of EDCI.HCl (277 mg, 1.451 mmol), HOBt (221 mg, 1.459 mmol) and triethylamine (403 μl, 2.905 mmol) in dichloromethane (10 ml) as described in Example 1 to give 311 mg of the product as a white solid; IR (KBr) 3204, 2972, 1632, 1523, 1230, 757 cm−1; 1H NMR (300 MHz, CDCl3) δ 1.67-1.73 (m, 2H), 2.06-2.31 (m, 6H), 2.66-2.71 (m, 2H), 3.31-3.39 (m, 2H), 4.05 (s, 3H), 5.05 (br s, 1H), 6.77 (d, J=9.0 Hz, 1H), 7.03 (d, J=8.4 Hz, 1H), 7.14 (d, J=8.4 Hz, 1H), 7.20 (s, 1H), 7.53-7.61 (m, 2H), 8.20-8.28 (m, 2H), 8.43 (d, J=8.4 Hz, 1H), 8.86 (d, J=8.7 Hz, 1H); ESI-MS (m/z) 464.17 (M+H)+.