Hydrochloric Acid → N-tert-butyl-6-[5-oxo-4-(pyridin-3-ylmethyl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-sulfonamide hydrochloride

HRID 45233Notes

Reaction equation

HRID 45233 reaction equation
[C:1]([NH:5][S:6]([C:9]1[CH:10]=[N:11][C:12]([N:15]2[C:19](=[O:20])[C:18]([CH2:21][C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)=[CH:17][NH:16]2)=[CH:13][CH:14]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].[ClH:28]>C(Cl)Cl>[ClH:28].[C:1]([NH:5][S:6]([C:9]1[CH:10]=[N:11][C:12]([N:15]2[C:19](=[O:20])[C:18]([CH2:21][C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)=[CH:17][NH:16]2)=[CH:13][CH:14]=1)(=[O:8])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67454087N-tert-butyl-6-[5-oxo-4-(pyridin-3-ylmethyl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-sulfonamide

Product 1

HCID 86659741N-tert-butyl-6-[5-oxo-4-(pyridin-3-ylmethyl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-sulfonamide hydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 912 mg of N-tert-butyl-6-[5-oxo-4-(pyridin-3-ylmethyl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-sulfonamide in 20 mL of DCM is added 1 eq. of HCl (4N in dioxane) and the medium is then concentrated under vacuum. 1 g of N-tert-butyl-6-[5-oxo-4-(pyridin-3-ylmethyl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-sulfonamide hydrochloride is obtained in the form of a white powder.

Workup

  1. concentrationthe medium is then concentrated under vacuum

Sources & evidence

ORD record
ord-4d4a70bf9c604312b7f574667fc18d32
Source dataset
uspto-grants-2013_09
Patent number
US08541455B2

Reaction notes

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