反应详情

36.5 g (113 mmol) of Z-Gly-Gly-OtBu were dissolved in 11 THF followed by the addition of 3.65 g palladium on charcoal (10%). The mixture was stirred under H2 atmosphere (1 atm) for 3 h at room temperature. The suspension was purged with N2, filtered (PTFE-filter: 0.45 μm) and the filtrate was concentrated under reduced pressure yielding 20.3 g (95%) Gly-Gly-O-tBu as a yellow oil. The crude material was pure enough for further synthesis.

1. customThe suspension was purged with N2
2. filtrationfiltered
3. filtration(PTFE-filter: 0.45 μm)
4. concentrationthe filtrate was concentrated under reduced pressure