HRID45236

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID175

Acetate

C2H3O2-

HCID2095679

N-ethyl-6-hydrazinyl-N-phenylpyridine-3-sulfonamide

C13H16N4O2S

HCID12200242

2-benzyl-3-ketoglutarate diethyl ester

C16H20O5

PRODUCTS

生成物

结构：CCOC(=O)Cc1[nH]n(-c2ccc(S(=O)(=O)N(CC)c3ccccc3)cn2)c(=O)c1Cc1ccccc1

HCID123772210

未命名化合物

PROCEDURE

实验过程

According to the process described in Example 1.3, starting with 5 g (17.1 mmol) of diethyl 2-benzyl-3-oxopentanedioate and 5 g (17.1 mmol) of N-ethyl-6-hydrazino-N-phenylpyridine-3-sulfonamide, 3 g of ethyl 4-benzyl-1-{5-[ethyl(phenyl)sulfamoyl]pyridin-2-yl}-5-oxo-2,5-dihydro-1H-pyrazol-3-yl)acetate are obtained in the form of a white powder.

WORKUP

后处理

customare obtained in the form of a white powder

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d1346910ee874305bbc5ae3d9da8c090
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08541455B2
来源说明: uspto-grants-2013_09

反应 SMILES

[CH2:1]([CH:8]([C:14](=O)[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:9]([O:11]CC)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:22]([N:24]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[S:25]([C:28]1[CH:29]=[N:30][C:31]([NH:34][NH2:35])=[CH:32][CH:33]=1)(=[O:27])=[O:26])[CH3:23].C([O-])(=O)C>>[CH2:1]([C:8]1[C:9](=[O:11])[N:34]([C:31]2[CH:32]=[CH:33][C:28]([S:25](=[O:27])(=[O:26])[N:24]([CH2:22][CH3:23])[C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)=[CH:29][N:30]=2)[NH:35][C:14]=1[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1