Ethanol → HCID 44481633, compound

HRID 452413Notes

Reaction equation

HRID 452413 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:13]([CH3:16])(=[O:15])=[O:14])[CH:11]=[CH:12][C:6]=2[CH2:5][O:4]1.[CH2:17]([NH2:21])[CH2:18][CH2:19][CH3:20].CCO>C(CC(C)(C)C)(C)C>[CH3:16][S:13]([C:10]1[CH:11]=[CH:12][C:6]2[CH2:5][O:4][CH:3]([CH2:2][NH:21][CH2:17][CH2:18][CH2:19][CH3:20])[O:8][C:7]=2[CH:9]=1)(=[O:15])=[O:14]

Participants

5

Reactant 3

HCID 702EthanolHCID 8007ButylamineHCID 668864402-(bromomethyl)-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 44481633HCID 44481633, compound

Reagents, catalysts & solvents 1

HCID 109072,2,4-TrimethylpentaneSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 2-(bromomethyl)-7-(methylsulfonyl)-4H-1,3-benzodioxine (30 mg, 0.10 mmol), n-butan-1-amine (0.50 ml, 5.1 mmol) and EtOH (1.0 ml) was heated under microwave radiation at 130° C. for 30 min. MS m/z (rel. intensity, 70 eV) 299 (M+, 1), 123 (8), 86 (bp), 77 (9), 72 (10).

Sources & evidence

ORD record
ord-fcc7d9369ac84858930d38916068ad7d
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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