Morpholine → 4-{[7-(Methylsulfonyl)-4H-1,3-benzodioxin-2-YL]methyl}morpholine

HRID 452419Notes

Reaction equation

HRID 452419 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:13]([CH3:16])(=[O:15])=[O:14])[CH:11]=[CH:12][C:6]=2[CH2:5][O:4]1.[NH:17]1[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>CCO>[CH3:16][S:13]([C:10]1[CH:11]=[CH:12][C:6]2[CH2:5][O:4][CH:3]([CH2:2][N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)[O:8][C:7]=2[CH:9]=1)(=[O:15])=[O:14]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 668864402-(bromomethyl)-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 444819024-{[7-(Methylsulfonyl)-4H-1,3-benzodioxin-2-YL]methyl}morpholine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to Example 22 using 2-(bromomethyl)-7-(methylsulfonyl)-4H-1,3-benzodioxine (30 mg, 0.10 mmol), morpholine (0.50 ml, 5.7 mmol) and EtOH (1.0 ml). MS m/z (rel. intensity, 70 eV) 313 (M+, 1), 101 (6), 100 (bp), 77 (4), 56 (6).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-3ded948f6e8f42e98859ffa26eff533f
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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