Ethanol → HCID 44482175, compound

HRID 452423Notes

Reaction equation

HRID 452423 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1.[CH2:18]([NH2:20])[CH3:19].CCO>C(CC(C)(C)C)(C)C>[F:13][C:12]1[C:6]2[CH2:5][O:4][CH:3]([CH2:2][NH:20][CH2:18][CH3:19])[O:8][C:7]=2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 6341EthylamineHCID 668876212-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 44482175HCID 44482175, compound

Reagents, catalysts & solvents 1

HCID 109072,2,4-TrimethylpentaneSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine (7 mg, 0.021 mmol), ethanamine (0.5 ml, 2 M in MeOH) and EtOH (3 ml) was heated under microwave radiation at 130° C. for 30 min. MS m/z (rel. intensity, 70 eV) 289 (M+, 0.3), 176 (7), 141 (8), 95 (9), 75 (10), 58 (bp).

Sources & evidence

ORD record
ord-a134c5a98d2c42c2b526b01ae701d9a5
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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