1-Propanamine, N-ethyl- → HCID 44482449, compound

HRID 452434Notes

Reaction equation

HRID 452434 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1.[CH2:18]([NH:20][CH2:21][CH2:22][CH3:23])[CH3:19]>CCO>[CH2:18]([N:20]([CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1)[CH2:21][CH2:22][CH3:23])[CH3:19]

Participants

4

Reactant 2

HCID 883981-Propanamine, N-ethyl-HCID 668876212-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 44482449HCID 44482449, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to Example 34 using 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine (8.5 mg, 0.026 mmol), N-ethylpropan-1-amine (0.5 ml) and EtOH (3 ml). MS m/z (rel. intensity, 70 eV) 331 (M+, 0.1), 101 (7), 100 (bp), 95 (5), 72 (14), 58 (12).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-6b19c0cd5de74c31bfe2219b3882a924
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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