2-Methoxyethylamine → HCID 44482451, compound

HRID 452436Notes

Reaction equation

HRID 452436 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1.[CH3:18][O:19][CH2:20][CH2:21][NH2:22]>CCO>[F:13][C:12]1[C:6]2[CH2:5][O:4][CH:3]([CH2:2][NH:22][CH2:21][CH2:20][O:19][CH3:18])[O:8][C:7]=2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=1

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 668876212-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 44482451HCID 44482451, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to Example 34 using 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine (8.5 mg, 0.026 mmol), 2-methyoxyethanamine (0.50 ml) and EtOH (3 ml). MS m/z (rel. intensity, 70 eV) 319 (M+, 0.3), 141 (17), 88 (bp), 72 (29), 58 (12), 56 (16).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-2dfb7980fd6340e9acd7f68e7e141390
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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