Neopentylamine → HCID 44478534, compound

HRID 452438Notes

Reaction equation

HRID 452438 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:12]([F:13])[C:6]=2[CH2:5][O:4]1.[CH3:18][C:19]([CH3:23])([CH3:22])[CH2:20][NH2:21]>CCO>[F:13][C:12]1[C:6]2[CH2:5][O:4][CH:3]([CH2:2][NH:21][CH2:20][C:19]([CH3:23])([CH3:22])[CH3:18])[O:8][C:7]=2[CH:9]=[C:10]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=1

Participants

4

Reactant 2

HCID 79882NeopentylamineHCID 668876212-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine

Product 1

HCID 44478534HCID 44478534, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to Example 34 using 2-(bromomethyl)-5-fluoro-7-(methylsulfonyl)-4H-1,3-benzodioxine (8.5 mg, 0.026 mmol), 2,2-dimethylpropan-1-amine (0.5 ml) and EtOH (3 ml). MS m/z (rel. intensity, 70 eV) 331 (M+, 1), 274 (74), 203 (20), 141 (32), 100 (bp), 72 (74).

Workup

  1. customPreparation

Sources & evidence

ORD record
ord-322021c146e14c84ae75d4b56d8a63c9
Source dataset
uspto-grants-2013_07
Patent number
US08492372B2

Reaction notes

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