HCID 13486182, compound → ethyl {2-[5-(tert-butylsulfamoyl)pyridin-2-yl]-3-oxo-2,3-dihydro-1H-pyrazol-4-yl}-(phenyl)acetate

HRID 45247Notes

Reaction equation

HRID 45247 reaction equation
[CH:1]([CH:3]([CH:9]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:4]([O:6]CC)=O)=O.[C:21]([NH:25][S:26]([C:29]1[CH:30]=[N:31][C:32]([NH:35][NH2:36])=[CH:33][CH:34]=1)(=[O:28])=[O:27])([CH3:24])([CH3:23])[CH3:22].C(NS(C1C=CC(N2C(=O)C(C(C3C=CC=CC=3)C(OC)=O)=CN2)=NC=1)(=O)=O)(C)(C)C>>[C:21]([NH:25][S:26]([C:29]1[CH:34]=[CH:33][C:32]([N:35]2[C:4](=[O:6])[C:3]([CH:9]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:1][NH:36]2)=[N:31][CH:30]=1)(=[O:28])=[O:27])([CH3:24])([CH3:22])[CH3:23]

Participants

4

Reactant 3

HCID 13486182HCID 13486182, compoundHCID 16777776HCID 16777776, compoundHCID 86659744methyl {2-[5-(tert-butylsulfamoyl)pyridin-2-yl]-3-oxo-2,3-dihydro-1H-pyrazol-4-yl}(phenyl)acetate

Product 1

HCID 86659743ethyl {2-[5-(tert-butylsulfamoyl)pyridin-2-yl]-3-oxo-2,3-dihydro-1H-pyrazol-4-yl}-(phenyl)acetate

Procedure

According to the process described in Example 27.2, starting with 2 g (7.19 mmol) of diethyl 2-formyl-3-phenylbutanedioate and 1.75 g (7.19 mmol) of N-tert-butyl-6-hydrazinylpyridine-3-sulfonamide, 3.1 g of methyl {2-[5-(tert-butylsulfamoyl)pyridin-2-yl]-3-oxo-2,3-dihydro-1H-pyrazol-4-yl}(phenyl)acetate are obtained in the form of a powder.

Workup

  1. customare obtained in the form of a powder

Sources & evidence

ORD record
ord-f8fe0cac2ea2482cb3c026f5c50bb6c8
Source dataset
uspto-grants-2013_09
Patent number
US08541455B2

Reaction notes

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