Hydroxylamine → 4-Bromo-3-nitrobenzaldoxime

HRID 452479Notes

Reaction equation

HRID 452479 reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[OH2:13].O[NH2:15]>CO>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[N:15][OH:13])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11]

Participants

5

Reactant 3

HCID 787HydroxylamineHCID 962WaterHCID 8087924-Bromo-3-nitrobenzaldehyde

Product 1

HCID 731663754-Bromo-3-nitrobenzaldoxime

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a solution of 5.0 g of 4-bromo-3-nitrobenzaldehyde in 50 ml of methanol, 3.6 ml of 50% hydroxyamine aqueous solution was added with stirring at room temperature, and continued to stir at the same temperature for 18 hours. After the completion of the reaction, 60 ml of water was added in the reaction mixture, and precipitated solid was filtered off, washed with water and then dried to obtain 5.0 g of the aimed product as yellow crystal.

Workup

  1. stirringto stir at the same temperature for 18 hours
  2. additionwas added in the reaction mixture
  3. customprecipitated solid
  4. filtrationwas filtered off
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-ddf93b45fff44fa39fa709d1d06acf28
Source dataset
uspto-grants-2013_07
Patent number
US08492311B2

Reaction notes

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