反应详情

In a mixture of 3.0 g of concentrated ammonia water and 15 ml of tetrahydrofuran, a solution of 3.0 g of 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-methylbenzoyl chloride in 20 ml of tetrahydrofuran was added dropwise, after the completion of the addition, continued to stir further for 18 hours. After the completion of the reaction, the solvent was distilled off under reduced pressure, the residue was dissolved in 50 ml of ethyl acetate, washed with 50 ml of water, dehydrated and dried with saturated sodium chloride aqueous solution and anhydrous sodium sulfate in that order, and the solvent was distilled off under reduced pressure to obtain 2.9 g of the aimed product as orange crystal.

1. additionafter the completion of the addition
2. customAfter the completion of the reaction
3. distillationthe solvent was distilled off under reduced pressure
4. dissolutionthe residue was dissolved in 50 ml of ethyl acetate
5. washwashed with 50 ml of water
6. dry with materialdried with saturated sodium chloride aqueous solution and anhydrous sodium sulfate in that order
7. distillationthe solvent was distilled off under reduced pressure