Carbon Disulfide → HCID 178464120, compound

HRID 452599Notes

Reaction equation

HRID 452599 reaction equation
[N:1]1[CH:2]=[N:3][N:4]2[CH:9]=[CH:8][C:7]([C:10]([NH:12][NH2:13])=[O:11])=[CH:6][C:5]=12.[C:14](=S)=[S:15].[CH2:17]([N:19]([CH2:22][CH3:23])[CH2:20][CH3:21])[CH3:18]>C(O)C>[CH2:17]([N:19]([CH2:22][CH3:23])[CH2:20][CH3:21])[CH3:18].[N:1]1[CH:2]=[N:3][N:4]2[CH:9]=[CH:8][C:7]([C:10]3[O:11][C:14]([SH:15])=[N:13][N:12]=3)=[CH:6][C:5]=12

Participants

5

Reactant 3

HCID 6348Carbon DisulfideHCID 8471TriethylamineHCID 686633301,2,4-Triazolo[1,5-a]pyridine-7-carbohydrazide

Product 1

HCID 178464120HCID 178464120, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 1,2,4-triazolo[1,5-a]pyridine-7-carbohydrazide (450 mg, 2.54 mmol), carbon disulfide (0.38 mL, 6.35 mmol), triethylamine (0.44 mL, 3.18 mmol) and ethanol (30 mL) was stirred at 90° C. for 18 hr. The reaction mixture was concentrated under reduced pressure to give the title compound (814 mg, yield 100%) as brown crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-16b0a287e37846ac938681af51303d23
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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