反应详情

A solution of quinoline-6-carbohydrazide (2.00 g, 10.7 mmol), carbon disulfide (1.61 mL, 26.8 mmol) and triethylamine (1.78 mL, 12.8 mmol) in ethanol (40 mL) was heated under reflux for 4 hr. After cooling, the reaction mixture was poured into water, a saturated aqueous ammonium chloride solution (100 mL) was added, and the mixture was saturated with sodium chloride. The precipitate was collected by filtration and recrystallized from methanol to give the title compound (1.24 g, yield 51%) as pale-yellow crystals.

1. temperatureunder reflux for 4 hr
2. temperatureAfter cooling
3. filtrationThe precipitate was collected by filtration
4. customrecrystallized from methanol