4-(Trifluoromethoxy)phenylboronic acid → Methyl 3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate

HRID 452647Notes

Reaction equation

HRID 452647 reaction equation
Br[C:2]1[C:6]2[CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH:3]=1.[F:15][C:16]([F:28])([F:27])[O:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[F:15][C:16]([F:27])([F:28])[O:17][C:18]1[CH:23]=[CH:22][C:21]([C:2]2[C:6]3[CH:7]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[CH:9]=[CH:10][C:5]=3[O:4][CH:3]=2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 22481688Methyl 3-bromo-1-benzofuran-5-carboxylate

Product 1

HCID 68664369Methyl 3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylateYield 74%

Procedure

In the same manner as in Reference Example 19 and using methyl 3-bromo-1-benzofuran-5-carboxylate instead of methyl 3-iodoimidazo[1,2-a]pyridine-6-carboxylate and [4-(trifluoromethoxy)phenyl]boronic acid instead of (4-methoxyphenyl)boronic acid, the title compound (yield 74%) was obtained as colorless crystals.

Sources & evidence

ORD record
ord-012678595a654270b42c874153b9326b
Source dataset
uspto-grants-2013_07
Patent number
US08492378B2

Reaction notes

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