HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethoxy)phenylboronic acid → Methyl 3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethoxy)phenylboronic acid | HCID 2734386 | — |
| Reactant | Methyl 3-bromo-1-benzofuran-5-carboxylate | HCID 22481688 | — |
| Product | Methyl 3-[4-(trifluoromethoxy)phenyl]-1-benzofuran-5-carboxylate | HCID 68664369 | 74% |
Reaction Steps
In the same manner as in Reference Example 19 and using methyl 3-bromo-1-benzofuran-5-carboxylate instead of methyl 3-iodoimidazo[1,2-a]pyridine-6-carboxylate and [4-(trifluoromethoxy)phenyl]boronic acid instead of (4-methoxyphenyl)boronic acid, the title compound (yield 74%) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08492378B2 |
| Source dataset | uspto-grants-2013_07 |
| ORD ID | ord-012678595a654270b42c874153b9326b |
| Source note | uspto-grants-2013_07 |